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In humans, a RCT enrolling 156 patients with a BMI 27 kg/m 2 failed to demonstrate that one year of liraglutide treatment could improve pain in patients with KOA compared to placebo, despite a significant BW difference of approximately 4 kg at end of study 105

8,9,10 These mechanisms make GLP-1RAs powerful tools for controlling blood glucose and improving metabolic syndrome

10.1016/j.cmet.2005.03.004 26

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It is believed that this proposed beneficial effect is based largely on the ability of these drugs to inhibit angiogenesis (Vagnucci and Li 2003)